3F73

Alignment of guide-target seed duplex within an argonaute silencing complex

Summary for 3F73

• Entry DOI: 10.2210/pdb3f73/pdb
• Related: 3DLB 3DLH
• Descriptor: ARGONAUTE, DNA (5'-D(P*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DA*DTP*DAP*DGP*DT)-3'), RNA (5'-R(*UP*AP*UP*AP*CP*AP*A*CP*UP*CP*AP*CP*UP*AP*CP*CP*UP*CP*GP*U)-3'), ... (6 entities in total)
• Functional Keywords: argonaute, protein-dna-rna-complex, nucleic acid binding protein-dna-rna complex, nucleic acid binding protein/dna/rna
• Biological source: Thermus thermophilus
• Total number of polymer chains: 6
• Total formula weight: 179299.39

Authors

Wang, Y.,Li, H.,Sheng, G.,Juranek, S.,Tuschl, T.,Patel, D.J. (deposition date: 2008-11-07, release date: 2008-12-16, Last modification date: 2023-09-06)

• Primary citation: Wang, Y.,Juranek, S.,Li, H.,Sheng, G.,Tuschl, T.,Patel, D.J.; Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.; Nature, 456:921-926, 2008; PubMed: 19092929; DOI: 10.1038/nature07666

Experimental method

X-RAY DIFFRACTION (3 Å)