3FR4
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors
Summary for 3FR4
Entry DOI | 10.2210/pdb3fr4/pdb |
Related | 3FR2 3FR5 |
Descriptor | Fatty acid-binding protein, adipocyte, 9-[2-(trifluoromethyl)benzyl]-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid (3 entities in total) |
Functional Keywords | selective adipocyte fatty-acid binding protein (a-fabp) inhibitors, cytoplasm, lipid-binding, nucleus, phosphoprotein, polymorphism, transport, lipid binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15090 |
Total number of polymer chains | 1 |
Total formula weight | 15113.27 |
Authors | Barf, T.,Hammer, K.,Lehmann, F.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundb ck, T. (deposition date: 2009-01-08, release date: 2009-03-10, Last modification date: 2024-02-21) |
Primary citation | Barf, T.,Lehmann, F.,Hammer, K.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundback, T. N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg.Med.Chem.Lett., 19:1745-1748, 2009 Cited by PubMed: 19217286DOI: 10.1016/j.bmcl.2009.01.084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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