3FR5

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors

Summary for 3FR5

Entry DOI	10.2210/pdb3fr5/pdb
Related	3FR2 3FR4
Descriptor	Fatty acid-binding protein, adipocyte, 5-(3-carbamoylbenzyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylic acid (3 entities in total)
Functional Keywords	selective adipocyte fatty-acid binding protein (a-fabp) inhibitors, cytoplasm, lipid-binding, nucleus, phosphoprotein, polymorphism, transport, lipid binding protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15090
Total number of polymer chains	1
Total formula weight	14971.12
Authors	Barf, T.,Hammer, K.,Lehmann, F.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundb ck, T. (deposition date: 2009-01-08, release date: 2009-03-10, Last modification date: 2024-02-21)
Primary citation	Barf, T.,Lehmann, F.,Hammer, K.,Haile, S.,Axen, E.,Medina, C.,Uppenberg, J.,Svensson, S.,Rondahl, L.,Lundback, T. N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg.Med.Chem.Lett., 19:1745-1748, 2009 Cited by PubMed: 19217286 DOI: 10.1016/j.bmcl.2009.01.084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation