3E7T

Structure of murine iNOS oxygenase domain with inhibitor AR-C102222

3E7T の概要

• エントリーDOI: 10.2210/pdb3e7t/pdb
• 関連するPDBエントリー: 3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T 3E7G 3E7I 3E7M 3E7S 3EAH 3EAI 3EBD 3EBF 3EJ8
• 分子名称: Nitric oxide synthase, inducible, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• 機能のキーワード: nitric oxide synthase, nos, heme, tetrahydrobiopterin, oxidoreductase calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102814.14

構造登録者

Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. (登録日: 2008-08-18, 公開日: 2008-10-07, 最終更新日: 2024-02-21)

• 主引用文献: Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D.; Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.; Nat.Chem.Biol., 4:700-707, 2008; PubMed: 18849972; DOI: 10.1038/nchembio.115

実験手法

X-RAY DIFFRACTION (2.6 Å)