3E7G

Structure of human INOSOX with inhibitor AR-C95791

Summary for 3E7G

Entry DOI	10.2210/pdb3e7g/pdb
Related	3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T
Descriptor	Nitric oxide synthase, inducible, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywords	nitric oxide, nos, heme, tetrahydrobiopterin, oxidoreductase, alternative splicing, calcium, calmodulin-binding, fad, fmn, iron, metal-binding, nadp, phosphoprotein, polymorphism, zinc
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	200814.55
Authors	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stueh, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. (deposition date: 2008-08-18, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4:700-707, 2008 Cited by PubMed: 18849972 DOI: 10.1038/nchembio.115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation