3BM6
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid
Summary for 3BM6
| Entry DOI | 10.2210/pdb3bm6/pdb |
| Related | 1C3B 1GA9 2I72 |
| Descriptor | Beta-lactamase, 4-(dihydroxyboranyl)-2-({[4-(phenylsulfonyl)thiophen-2-yl]sulfonyl}amino)benzoic acid (3 entities in total) |
| Functional Keywords | ampc, beta-lactamases, cephalosporinase, serine hydrolase, covalent inhibition, antibiotic resistance, periplasm, hydrolase |
| Biological source | Escherichia coli |
| Cellular location | Periplasm: P00811 |
| Total number of polymer chains | 2 |
| Total formula weight | 80110.45 |
| Authors | Tondi, D. (deposition date: 2007-12-12, release date: 2009-02-17, Last modification date: 2023-08-30) |
| Primary citation | Tondi, D.,Calo, S.,Shoichet, B.K.,Costi, M.P. Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg.Med.Chem.Lett., 20:3416-3419, 2010 Cited by PubMed: 20452208DOI: 10.1016/j.bmcl.2010.04.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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