2I72
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid
Summary for 2I72
Entry DOI | 10.2210/pdb2i72/pdb |
Related | 1CB3 1KE4 |
Descriptor | Beta-lactamase, {5-[(DIFORMYLAMINO)METHYL]-1-BENZOTHIEN-2-YL}BORONIC ACID (3 entities in total) |
Functional Keywords | ampc, beta-lactamase, cephalosporinase, serine hydrolase, hydrolase |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 79702.00 |
Authors | Venturelli, A.,Cancian, L.,Tondi, D.,Morandi, F.,Cannazza, G.,Segatore, B.,Prati, F.,Amicosante, G.,Shoichet, B.K.,Costi, M.P. (deposition date: 2006-08-30, release date: 2007-09-11, Last modification date: 2023-08-30) |
Primary citation | Venturelli, A.,Tondi, D.,Cancian, L.,Morandi, F.,Cannazza, G.,Segatore, B.,Prati, F.,Amicosante, G.,Shoichet, B.K.,Costi, M.P. Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy J.Med.Chem., 50:5644-5654, 2007 Cited by PubMed: 17956081DOI: 10.1021/jm070643q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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