2XYJ

Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

Summary for 2XYJ

Entry DOI	10.2210/pdb2xyj/pdb
Related	1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2XYW 2XYX 3GWX
Descriptor	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, 5-CHLORO-2-METHOXY-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]BENZAMIDE, PENTAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	transcription
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	68210.83
Authors	Marquette, J.-P.,Mathieu, M. (deposition date: 2010-11-18, release date: 2011-02-23, Last modification date: 2024-05-01)
Primary citation	Keil, S.,Matter, H.,Schonafinger, K.,Glien, M.,Mathieu, M.,Marquette, J.-P.,Michot, N.,Haag-Diergarten, S.,Urmann, M.,Wendler, W. Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6:633-, 2011 Cited by PubMed: 21400663 DOI: 10.1002/CMDC.201100047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation