2XU1
CATHEPSIN L WITH A NITRILE INHIBITOR
Summary for 2XU1
Entry DOI | 10.2210/pdb2xu1/pdb |
Related | 1CJL 1CS8 1ICF 1MHW 2VHS 2XU3 2XU4 2XU5 |
Descriptor | CATHEPSIN L1, (2S,4R)-1-[1-(4-chlorophenyl)cyclopropyl]carbonyl-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide (3 entities in total) |
Functional Keywords | hydrolase, drug design, thiol protease |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 4 |
Total formula weight | 98784.52 |
Authors | Banner, D.W.,Benz, J.M.,Steinbacher, S.,Haap, W. (deposition date: 2010-10-14, release date: 2011-01-12, Last modification date: 2011-07-13) |
Primary citation | Hardegger, L.A.,Kuhn, B.,Spinnler, B.,Anselm, L.,Ecabert, R.,Stihle, M.,Gsell, B.,Thoma, R.,Diez, J.,Benz, J.,Plancher, J.M.,Hartmann, G.,Banner, D.W.,Haap, W.,Diederich, F. Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 50:314-, 2011 Cited by PubMed: 21184410DOI: 10.1002/ANIE.201006781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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