2XH5
Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB
Replaces: 2X37Summary for 2XH5
Entry DOI | 10.2210/pdb2xh5/pdb |
Related | 1GNG 1GZK 1GZN 1GZO 1H8F 1I09 1J1B 1J1C 1MRV 1MRY 1O6K 1O6L 1O9U 1P6S 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X39 |
Descriptor | RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-(4-tert-butylbenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium, ... (4 entities in total) |
Functional Keywords | serine/threonine-protein kinase, nucleotide-binding, wnt signaling pathway, kinase, transferase, phosphoprotein |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 2 |
Total formula weight | 41348.11 |
Authors | Davies, T.G.,McHardy, T.,Caldwell, J.J.,Cheung, K.M.,Hunter, L.J.,Taylor, K.,Rowlands, M.,Ruddle, R.,Henley, A.,Brandon, A.D.,Valenti, M.,Fazal, L.,Seavers, L.,Raynaud, F.I.,Eccles, S.A.,Aherne, G.W.,Garrett, M.D.,Collins, I. (deposition date: 2010-06-09, release date: 2010-06-16, Last modification date: 2011-07-13) |
Primary citation | Mchardy, T.,Caldwell, J.J.,Cheung, K.M.,Hunter, L.J.,Taylor, K.,Rowlands, M.,Ruddle, R.,Henley, A.,De Haven Brandon, A.,Valenti, M.,Davies, T.G.,Fazal, L.,Seavers, L.,Raynaud, F.I.,Eccles, S.A.,Aherne, G.W.,Garrett, M.D.,Collins, I. Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt). J.Med.Chem., 53:2239-, 2010 Cited by PubMed: 20151677DOI: 10.1021/JM901788J PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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