2UW9
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine
Summary for 2UW9
Entry DOI | 10.2210/pdb2uw9/pdb |
Related | 1GNG 1GZK 1GZN 1GZO 1H8F 1I09 1J1B 1J1C 1MRV 1MRY 1O6K 1O6L 1O9U 1P6S 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR |
Descriptor | RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, ... (4 entities in total) |
Functional Keywords | transferase/inhibitor, transferase-inhibitor complex, wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, atp-binding, phosphorylation, nucleotide-binding, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 2 |
Total formula weight | 41321.45 |
Authors | Davies, T.G.,Saxty, G.,Woodhead, S.J.,Berdini, V.,Verdonk, M.L.,Wyatt, P.G.,Boyle, R.G.,Barford, D.,Downham, R.,Garrett, M.D.,Carr, R.A. (deposition date: 2007-03-19, release date: 2007-05-08, Last modification date: 2011-07-13) |
Primary citation | Saxty, G.,Woodhead, S.J.,Berdini, V.,Davies, T.G.,Verdonk, M.L.,Wyatt, P.G.,Boyle, R.G.,Barford, D.,Downham, R.,Garrett, M.D.,Carr, R.A. Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery. J.Med.Chem., 50:2293-, 2007 Cited by PubMed: 17451234DOI: 10.1021/JM070091B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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