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2V5X

Crystal structure of HDAC8-inhibitor complex

Summary for 2V5X
Entry DOI10.2210/pdb2v5x/pdb
Related1T64 1T67 1T69 1VKG 1W22 2V5W
DescriptorHISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywordshydroxamate inhibitor, chromatin regulator, histone deacetylase, p53, hdac, hdac8, nucleus, hydrolase, repressor, chromatin, drug design, deacetylation, transcription, transcription regulation, nuclear protein, peptidic substrate
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight87940.59
Authors
Di Marco, S.,Vannini, A.,Volpari, C.,Gallinari, P.,Jones, P.,Mattu, M.,Carfi, A.,Defrancesco, R.,Steinkuhler, C. (deposition date: 2007-07-10, release date: 2007-09-04, Last modification date: 2023-12-13)
Primary citationVannini, A.,Volpari, C.,Gallinari, P.,Jones, P.,Mattu, M.,Carfi, A.,Defrancesco, R.,Steinkuhler, C.,Di Marco, S.
Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8:879-, 2007
Cited by
PubMed: 17721440
DOI: 10.1038/SJ.EMBOR.7401047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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