2JWA

ErbB2 transmembrane segment dimer spatial structure

2JWA の概要

• エントリーDOI: 10.2210/pdb2jwa/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2 (1 entity in total)
• 機能のキーワード: transmembrane helix dimer, erbb2, protein kinase receptor membrane domain, atp-binding, glycoprotein, nucleotide-binding, phosphorylation, polymorphism, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9469.61

構造登録者

Mineev, K.S.,Bocharov, E.V.,Arseniev, A.S. (登録日: 2007-10-09, 公開日: 2008-01-22, 最終更新日: 2022-03-16)

• 主引用文献: Bocharov, E.V.,Mineev, K.S.,Volynsky, P.E.,Ermolyuk, Y.S.,Tkach, E.N.,Sobol, A.G.,Chupin, V.V.,Kirpichnikov, M.P.,Efremov, R.G.,Arseniev, A.S.; Spatial Structure of the Dimeric Transmembrane Domain of the Growth Factor Receptor ErbB2 Presumably Corresponding to the Receptor Active State; J.Biol.Chem., 283:6950-6956, 2008; PubMed: 18178548; DOI: 10.1074/jbc.M709202200

実験手法

SOLUTION NMR