2J5F

Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab

Summary for 2J5F

Entry DOI	10.2210/pdb2j5f/pdb
Related	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E
Descriptor	EPIDERMAL GROWTH FACTOR RECEPTOR, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total)
Functional Keywords	cell cycle, atp-binding, transferase, polymorphism, irreversible inhibitor, tyrosine-protein kinase, egfr, kinase, 34-jab, membrane, receptor, wild-type, epidermal growth factor, anti-oncogene, transmembrane, nucleotide-binding, alternative splicing, ubl conjugation, phosphorylation, disease mutation, glycoprotein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37673.34
Authors	Yun, C.-H.,Eck, M.J. (deposition date: 2006-09-14, release date: 2007-02-27, Last modification date: 2023-12-13)
Primary citation	Blair, J.A.,Rauh, D.,Kung, C.,Yun, C.-H.,Fan, Q.-W.,Rode, H.,Zhang, C.,Eck, M.J.,Weiss, W.A.,Shokat, K.M. Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics. Nat.Chem.Biol., 3:229-, 2007 Cited by PubMed: 17334377 DOI: 10.1038/NCHEMBIO866 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation