2J5E
Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab
Summary for 2J5E
Entry DOI | 10.2210/pdb2j5e/pdb |
Related | 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5F |
Descriptor | EPIDERMAL GROWTH FACTOR RECEPTOR, CHLORIDE ION (3 entities in total) |
Functional Keywords | cell cycle, atp-binding, transferase, polymorphism, irreversible inhibitor, tyrosine-protein kinase, egfr, kinase, 13-jab, membrane, receptor, wild-type, epidermal growth factor, anti-oncogene, transmembrane, nucleotide-binding, alternative splicing, ubl conjugation, phosphorylation, disease mutation, glycoprotein |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37629.90 |
Authors | Yun, C.-H.,Eck, M.J. (deposition date: 2006-09-14, release date: 2007-02-27, Last modification date: 2023-12-13) |
Primary citation | Blair, J.A.,Rauh, D.,Kung, C.,Yun, C.-H.,Fan, Q.-W.,Rode, H.,Zhang, C.,Eck, M.J.,Weiss, W.A.,Shokat, K.M. Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics. Nat.Chem.Biol., 3:229-, 2007 Cited by PubMed: 17334377DOI: 10.1038/NCHEMBIO866 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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