2GS2

Crystal Structure of the active EGFR kinase domain

Summary for 2GS2

Entry DOI	10.2210/pdb2gs2/pdb
Related	2GS6 2GS7
Descriptor	Epidermal growth factor receptor (2 entities in total)
Functional Keywords	egfr, kinase, active, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37563.46
Authors	Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. (deposition date: 2006-04-25, release date: 2006-06-20, Last modification date: 2023-08-30)
Primary citation	Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell(Cambridge,Mass.), 125:1137-1149, 2006 Cited by PubMed: 16777603 DOI: 10.1016/j.cell.2006.05.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation