2GS6

Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate

Summary for 2GS6

Entry DOI	10.2210/pdb2gs6/pdb
Related	2GS2 2GS7
Descriptor	Epidermal growth factor receptor, Peptide, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	egfr, kinase, active, atp-analog peptide conjugate, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	39723.87
Authors	Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. (deposition date: 2006-04-25, release date: 2006-06-20, Last modification date: 2023-08-30)
Primary citation	Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell(Cambridge,Mass.), 125:1137-1149, 2006 Cited by PubMed: 16777603 DOI: 10.1016/j.cell.2006.05.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation