1M14

Tyrosine Kinase Domain from Epidermal Growth Factor Receptor

Summary for 1M14

Entry DOI	10.2210/pdb1m14/pdb
Related	1M17
Descriptor	Epidermal growth factor receptor (2 entities in total)
Functional Keywords	transferase, tyrosine kinase domain
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37875.75
Authors	Stamos, J.,Sliwkowski, M.X.,Eigenbrot, C. (deposition date: 2002-06-17, release date: 2002-09-04, Last modification date: 2024-02-14)
Primary citation	Stamos, J.,Sliwkowski, M.X.,Eigenbrot, C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J.Biol.Chem., 277:46265-46272, 2002 Cited by PubMed: 12196540 DOI: 10.1074/jbc.M207135200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation