2HH0

Structure of an Anti-PrP Fab, P-Clone, in Complex with its Cognate Bovine Peptide Epitope.

2HH0 の概要

• エントリーDOI: 10.2210/pdb2hh0/pdb
• 分子名称: Light Chain, P-Clone Fab, Chimera, Heavy Chain, P-Clone Fab, Chimera, Prion protein, ... (4 entities in total)
• 機能のキーワード: prion, prp, fab, immune system
• 由来する生物種: Mus musculus, Homo sapiens (house mouse, human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 47366.76

構造登録者

Kanyo, Z.K. (登録日: 2006-06-27, 公開日: 2006-12-26, 最終更新日: 2017-10-11)

• 主引用文献: Luginbuhl, B.,Kanyo, Z.,Jones, R.M.,Fletterick, R.J.,Prusiner, S.B.,Cohen, F.E.,Williamson, R.A.,Burton, D.R.,Pluckthun, A.; Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation; J.Mol.Biol., 363:75-97, 2006; PubMed: 16962610; DOI: 10.1016/j.jmb.2006.07.027

実験手法

X-RAY DIFFRACTION (2.85 Å)