1UOL

Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.

Summary for 1UOL

Entry DOI	10.2210/pdb1uol/pdb
Related	1A1U 1AIE 1DT7 1GZH 1H26 1HS5 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCR 1YCS 3SAK
Descriptor	CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
Functional Keywords	dna-binding protein, p53, dna-binding domain, tumor suppressor, second-site suppressor mutation, superstable mutant, apoptosis, transcription regulation, dna binding protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	2
Total formula weight	49312.50
Authors	Joerger, A.C.,Allen, M.D.,Fersht, A.R. (deposition date: 2003-09-19, release date: 2003-10-16, Last modification date: 2011-07-13)
Primary citation	Joerger, A.C.,Allen, M.D.,Fersht, A.R. Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations J.Biol.Chem., 279:1291-, 2004 Cited by PubMed: 14534297 DOI: 10.1074/JBC.M309732200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation