1GZH

Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor

Summary for 1GZH

Entry DOI	10.2210/pdb1gzh/pdb
Related	1A1U 1AIE 1DT7 1HS5 1KZY 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCS 3SAK
Descriptor	CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (6 entities in total)
Functional Keywords	gene regulation, anti-oncogene, dna-binding, transcription regulation, bcrt domain, apoptosis, disease mutation, activator, dna- repair
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 P04637 Nucleus: Q12888
Total number of polymer chains	4
Total formula weight	101411.68
Authors	Derbyshire, D.J.,Doherty, A.J. (deposition date: 2002-05-22, release date: 2002-06-27, Last modification date: 2023-12-13)
Primary citation	Derbyshire, D.J.,Basu, B.P.,Serpell, L.,Joo, W.,Date, T.,Iwabuchi, K.,Doherty, A.J. Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor Embo J., 21:3863-, 2002 Cited by PubMed: 12110597 DOI: 10.1093/EMBOJ/CDF383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation