1TW6

Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac

Summary for 1TW6

Entry DOI	10.2210/pdb1tw6/pdb
Related	1NW9 1OXN 1OXQ 1OY7
Descriptor	Baculoviral IAP repeat-containing protein 7, Diablo homolog, mitochondrial, ZINC ION, ... (7 entities in total)
Functional Keywords	zinc binding, peptide complex, apoptosis inhibition, inhibitor-apoptosis complex, inhibitor/apoptosis
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q96CA5 Mitochondrion: Q9NR28
Total number of polymer chains	4
Total formula weight	32280.51
Authors	Franklin, M.C.,Vucic, D.,Wallweber, H.J.A.,Das, K.,Shin, H.,Elliott, L.O.,Kadkhodayan, S.,Deshayes, K.,Salvesen, G.S.,Fairbrother, W.J. (deposition date: 2004-06-30, release date: 2004-11-02, Last modification date: 2023-08-23)
Primary citation	Vucic, D.,Franklin, M.C.,Wallweber, H.J.A.,Das, K.,Eckelman, B.P.,Shin, H.,Elliott, L.O.,Kadkhodayan, S.,Deshayes, K.,Salvesen, G.S.,Fairbrother, W.J. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP Biochem.J., 385:11-20, 2005 Cited by PubMed: 15485396 DOI: 10.1042/BJ20041108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.713 Å)

Structure validation