1TW6
Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Baculoviral IAP repeat-containing protein 7 | polymer | 133 | 14961.6 | 2 | UniProt (Q96CA5) Pfam (PF00653) In PDB | Homo sapiens (human) | Kidney inhibitor of apoptosis protein, KIAP, Melanoma inhibitor of apoptosis protein, ML-IAP, Livin, UNQ5800/PRO19607/PRO21344, XIAP-BIR3 chimera |
| 2 | C, D | Diablo homolog, mitochondrial | polymer | 9 | 943.1 | 2 | UniProt (Q9NR28) In PDB | Homo sapiens (human) | Second mitochondria-derived activator of caspase, Smac protein, Direct IAP binding protein with low pI |
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | B | LITHIUM ION | non-polymer | 6.9 | 1 | Chemie (LI) | |||
| 5 | B | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
| 6 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A, B: 63 - 171 (UniProt: Q96CA5)
| PDB | External Database | Details |
|---|---|---|
| Met 40 | - | initiating methionine |
| Gly 41 | - | expression tag |
| Ser 42 | - | expression tag |
| Ser 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| His 48 | - | expression tag |
| His 49 | - | expression tag |
| Ser 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Leu 53 | - | expression tag |
| Val 54 | - | expression tag |
| Pro 55 | - | expression tag |
| Arg 56 | - | expression tag |
| Gly 57 | - | expression tag |
| Ser 58 | - | expression tag |
| His 59 | - | expression tag |
| Met 60 | - | expression tag |
| Leu 61 | - | expression tag |
| Glu 62 | - | expression tag |
| Gly 150 | Ser 150 | SEE REMARK 999 |
| Gly 70 | Arg 160 | SEE REMARK 999 |
| Glu 161 | Asp 161 | SEE REMARK 999 |
| Tyr 162 | Phe 162 | SEE REMARK 999 |
| Ile 163 | Val 163 | SEE REMARK 999 |
| Asn 164 | His 164 | SEE REMARK 999 |
| Asn 165 | Ser 165 | SEE REMARK 999 |
| Ile 166 | Val 166 | SEE REMARK 999 |
| His 167 | Gln 167 | SEE REMARK 999 |
| Leu 168 | Glu 168 | SEE REMARK 999 |
| Leu 172 | Gln 172 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 31809.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 471.1 | |
| All* | Total formula weight | 32280.5 |
