1T5X

HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2

Summary for 1T5X

Entry DOI	10.2210/pdb1t5x/pdb
Related	1AQD 1DLH 1KLU 1PYW 1T5W
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, 15-mer peptide fragment of Regulatory protein MIG1, ... (5 entities in total)
Functional Keywords	mhc class ii; major histocompatibiloty complex protein; hla-dr1; superantigen; antigen; peptide, immune system
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P01903 P04229 Nucleus: P27705 Secreted: P0A0L5
Total number of polymer chains	4
Total formula weight	72448.27
Authors	Zavala-Ruiz, Z.,Strug, I.,Anderson, M.W.,Gorski, J.,Stern, L.J. (deposition date: 2004-05-05, release date: 2004-08-17, Last modification date: 2023-08-23)
Primary citation	Zavala-Ruiz, Z.,Strug, I.,Anderson, M.W.,Gorski, J.,Stern, L.J. A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins Chem.Biol., 11:1395-1402, 2004 Cited by PubMed: 15489166 DOI: 10.1016/j.chembiol.2004.08.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation