1KLU

Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

Summary for 1KLU

Entry DOI	10.2210/pdb1klu/pdb
Related	1KLG
Descriptor	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN, Triosephosphate isomerase peptide, ... (5 entities in total)
Functional Keywords	hla-dr1/tpi, enterotoxin c3, human melanoma antigen, cd4+ t cells, immune system-toxin complex, immune system/toxin
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P01903 P04229 Secreted: P0A0L5
Total number of polymer chains	4
Total formula weight	72055.85
Authors	Sundberg, E.J.,Sawicki, M.W.,Andersen, P.S.,Sidney, J.,Sette, A.,Mariuzza, R.A. (deposition date: 2001-12-12, release date: 2002-08-02, Last modification date: 2021-10-27)
Primary citation	Sundberg, E.J.,Sawicki, M.W.,Southwood, S.,Andersen, P.S.,Sette, A.,Mariuzza, R.A. Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line. J.Mol.Biol., 319:449-461, 2002 Cited by PubMed: 12051920 DOI: 10.1016/S0022-2836(02)00370-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation