1SC7
Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex
Summary for 1SC7
Entry DOI | 10.2210/pdb1sc7/pdb |
Related | 1K4S 1K4T |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (6 entities in total) |
Functional Keywords | complex (isomerase-dna), dna, topoisomerase i, drug, poison, idenoisoquinoline, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 4 |
Total formula weight | 84243.52 |
Authors | Staker, B.L.,Feese, M.D.,Cushman, M.,Pommier, Y.,Zembower, D.,Stewart, L.,Burgin, A.B. (deposition date: 2004-02-11, release date: 2005-04-19, Last modification date: 2011-07-13) |
Primary citation | Staker, B.L.,Feese, M.D.,Cushman, M.,Pommier, Y.,Zembower, D.,Stewart, L.,Burgin, A.B. Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48:2336-2345, 2005 Cited by PubMed: 15801827DOI: 10.1021/jm049146p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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