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1K4T

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Summary for 1K4T
Entry DOI10.2210/pdb1k4t/pdb
Related1A31 1A35 1A36 1K4S
Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (9 entities in total)
Functional Keywordscomplex (isomerase-dna), dna, topoisomerase i, drug, poison, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus: P11387
Total number of polymer chains4
Total formula weight84971.68
Authors
Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J. (deposition date: 2001-10-08, release date: 2002-12-04, Last modification date: 2023-11-15)
Primary citationStaker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J.
The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99:15387-15392, 2002
Cited by
PubMed: 12426403
DOI: 10.1073/pnas.242259599
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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