Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003917 | molecular_function | DNA topoisomerase type I (single strand cut, ATP-independent) activity |
A | 0005694 | cellular_component | chromosome |
A | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TTC D 990 |
Chain | Residue |
A | ARG364 |
D | DC112 |
D | DA113 |
D | HOH1002 |
A | LYS532 |
A | ASP533 |
A | THR718 |
B | DT10 |
D | HOH3 |
C | TGP11 |
C | HOH28 |
C | HOH133 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE HG A 900 |
Chain | Residue |
A | ARG590 |
A | LEU629 |
A | CYS630 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE TTG C 991 |
Chain | Residue |
A | ARG364 |
A | LYS532 |
A | ASP533 |
A | THR718 |
A | ASN722 |
A | PTR723 |
B | DT10 |
D | HOH3 |
C | TGP11 |
C | HOH28 |
C | HOH133 |
D | DC112 |
D | DA113 |
D | HOH997 |
D | HOH1002 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 A 901 |
Chain | Residue |
A | ASP500 |
A | GLU510 |
A | HIS511 |
A | LEU530 |
Functional Information from PROSITE/UniProt
site_id | PS00176 |
Number of Residues | 19 |
Details | TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EnkqialGTSKlnYLdprI |
Chain | Residue | Details |
A | GLU710-ILE728 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | PTR723 | |
site_id | SWS_FT_FI2 |
Number of Residues | 9 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | ARG316 | |
A | ARG364 | |
A | TRP412 | |
A | LYS443 | |
A | THR501 | |
A | LYS532 | |
A | ASN574 | |
A | HIS632 | |
A | LYS650 | |
Chain | Residue | Details |
A | LYS280 | |
Chain | Residue | Details |
A | SER506 | |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS204 | |
A | LYS549 | |
A | LYS642 | |
A | LYS700 | |
A | LYS712 | |
Chain | Residue | Details |
A | LYS336 | |