1SC7

Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'	polymer	10	3061.1	1
2	C	5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'	polymer	12	3716.5	1
3	D	5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'	polymer	22	6690.4	1
4	A	DNA topoisomerase I	polymer	592	70248.0	1	UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB	Homo sapiens (human)
5	C	4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE	non-polymer		333.3	1	Chemie (M38)
6	A	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)

Sequence modifications

A: 174 - 765 (UniProt: P11387)

PDB	External Database	Details
Ptr 723	Tyr 723	MODIFIED RESIDUE

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	83716.0
Non-Polymers*	Number of molecules	2
	Total formula weight	527.6
All*	Total formula weight	84243.5

*Water molecules are not included.