1R6A
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
1R6A の概要
エントリーDOI | 10.2210/pdb1r6a/pdb |
関連するPDBエントリー | 1L9K |
分子名称 | Genome polyprotein, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
機能のキーワード | ribavirin 5'-triphosphate, dengue virus, 2'o methyltransferase, transferase |
由来する生物種 | Dengue virus 2 Puerto Rico/PR159-S1/1969 |
細胞内の位置 | Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P12823 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34526.71 |
構造登録者 | Benarroch, D.,Egloff, M.P.,Mulard, L.,Romette, J.L.,Canard, B. (登録日: 2003-10-15, 公開日: 2004-09-21, 最終更新日: 2024-02-14) |
主引用文献 | Benarroch, D.,Egloff, M.P.,Mulard, L.,Guerreiro, C.,Romette, J.L.,Canard, B. A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J.Biol.Chem., 279:35638-35643, 2004 Cited by PubMed: 15152003DOI: 10.1074/jbc.M400460200 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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