1L9K

dengue methyltransferase

Summary for 1L9K

• Entry DOI: 10.2210/pdb1l9k/pdb
• Descriptor: RNA-DIRECTED RNA POLYMERASE, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase fold, complex with s-adenosyl-l-homocysteine, transferase
• Biological source: Dengue virus
• Cellular location: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P12823
• Total number of polymer chains: 1
• Total formula weight: 35261.75

Authors

Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B. (deposition date: 2002-03-25, release date: 2003-03-25, Last modification date: 2024-02-14)

• Primary citation: Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B.; An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization; Embo J., 21:2757-2768, 2002; PubMed: 12032088; DOI: 10.1093/emboj/21.11.2757

Experimental method

X-RAY DIFFRACTION (2.4 Å)