1QUR

HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR

1QUR の概要

• エントリーDOI: 10.2210/pdb1qur/pdb
• 分子名称: HUMAN THROMBIN (ALPHA CHAIN), HUMAN THROMBIN (BETA CHAIN), BIVALENT INHIBITOR (BZA-2 HIRULOG), ... (4 entities in total)
• 機能のキーワード: trypsin like serine protease, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35187.25

構造登録者

Renatus, M.,Steinmetzer, T. (登録日: 1999-07-02, 公開日: 1999-10-14, 最終更新日: 2023-11-15)

• 主引用文献: Steinmetzer, T.,Renatus, M.,Kunzel, S.,Eichinger, A.,Bode, W.,Wikstrom, P.,Hauptmann, J.,Sturzebecher, J.; Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.; Eur.J.Biochem., 265:598-605, 1999; PubMed: 10504391; DOI: 10.1046/j.1432-1327.1999.00742.x

実験手法

X-RAY DIFFRACTION (2 Å)