1QUR

HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR

Summary for 1QUR

• Entry DOI: 10.2210/pdb1qur/pdb
• Descriptor: HUMAN THROMBIN (ALPHA CHAIN), HUMAN THROMBIN (BETA CHAIN), BIVALENT INHIBITOR (BZA-2 HIRULOG), ... (4 entities in total)
• Functional Keywords: trypsin like serine protease, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35187.25

Authors

Renatus, M.,Steinmetzer, T. (deposition date: 1999-07-02, release date: 1999-10-14, Last modification date: 2023-11-15)

• Primary citation: Steinmetzer, T.,Renatus, M.,Kunzel, S.,Eichinger, A.,Bode, W.,Wikstrom, P.,Hauptmann, J.,Sturzebecher, J.; Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.; Eur.J.Biochem., 265:598-605, 1999; PubMed: 10504391; DOI: 10.1046/j.1432-1327.1999.00742.x

Experimental method

X-RAY DIFFRACTION (2 Å)