1OHK

HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM

1OHK の概要

• エントリーDOI: 10.2210/pdb1ohk/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22668.51

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W. (登録日: 1997-09-17, 公開日: 1998-05-27, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Blakley, R.L.; Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.; Biochemistry, 36:13897-13903, 1997; PubMed: 9374868; DOI: 10.1021/bi971711l

実験手法

X-RAY DIFFRACTION (2.5 Å)