1OHK

HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM

Summary for 1OHK

• Entry DOI: 10.2210/pdb1ohk/pdb
• Descriptor: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22668.51

Authors

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W. (deposition date: 1997-09-17, release date: 1998-05-27, Last modification date: 2024-02-14)

• Primary citation: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Blakley, R.L.; Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.; Biochemistry, 36:13897-13903, 1997; PubMed: 9374868; DOI: 10.1021/bi971711l

Experimental method

X-RAY DIFFRACTION (2.5 Å)