1O3P

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

1O3P の概要

• エントリーDOI: 10.2210/pdb1o3p/pdb
• 関連するPDBエントリー: 1C5X
• 分子名称: Urokinase-type plasminogen activator, CITRIC ACID, 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-6-(CYCLOPENTYLOXY)BENZENOLATE, ... (5 entities in total)
• 機能のキーワード: serine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, blood clotting, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00749 P00749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31864.25

構造登録者

Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W. (登録日: 2003-03-06, 公開日: 2003-09-02, 最終更新日: 2023-12-27)

• 主引用文献: Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.; Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.; J.Mol.Biol., 329:93-120, 2003; PubMed: 12742021; DOI: 10.1016/S0022-2836(03)00399-1

実験手法

X-RAY DIFFRACTION (1.81 Å)