1O3P

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O3P

• Entry DOI: 10.2210/pdb1o3p/pdb
• Related: 1C5X
• Descriptor: Urokinase-type plasminogen activator, CITRIC ACID, 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-6-(CYCLOPENTYLOXY)BENZENOLATE, ... (5 entities in total)
• Functional Keywords: serine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, blood clotting, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749 P00749
• Total number of polymer chains: 2
• Total formula weight: 31864.25

Authors

Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W. (deposition date: 2003-03-06, release date: 2003-09-02, Last modification date: 2023-12-27)

• Primary citation: Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.; Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.; J.Mol.Biol., 329:93-120, 2003; PubMed: 12742021; DOI: 10.1016/S0022-2836(03)00399-1

Experimental method

X-RAY DIFFRACTION (1.81 Å)