1LPG
CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.
Summary for 1LPG
Entry DOI | 10.2210/pdb1lpg/pdb |
Related | 1LPK 1LPZ 1LQD 1LQE |
Descriptor | Blood coagulation factor Xa, CALCIUM ION, [4-({[5-BENZYLOXY-1-(3-CARBAMIMIDOYL-BENZYL)-1H-INDOLE-2-CARBONYL]-AMINO}-METHYL)-PHENYL]-TRIMETHYL-AMMONIUM, ... (5 entities in total) |
Functional Keywords | protein inhibitor complex, blood coagulation factor, serine proteinase, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 44348.15 |
Authors | Schreuder, H.A.,Brachvogel, V.,Liesum, A. (deposition date: 2002-05-08, release date: 2003-05-08, Last modification date: 2011-07-13) |
Primary citation | Matter, H.,Defossa, E.,Heinelt, U.,Blohm, P.M.,Schneider, D.,Mueller, A.,Herok, S.,Schreuder, H.,Liesum, A.,Brachvogel, B.,Loenze, P.,Walser, A.,Al-Obeidi, F.,Wildgoose, P. Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa. J.Med.Chem., 45:2749-2769, 2002 Cited by PubMed: 12061878DOI: 10.1021/jm0111346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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