1LPK
CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.
Summary for 1LPK
| Entry DOI | 10.2210/pdb1lpk/pdb |
| Related | 1LPG 1LPZ 1LQD 1LQE |
| Descriptor | Blood coagulation factor Xa, CALCIUM ION, 1-(3-CARBAMIMIDOYL-BENZYL)-1H-INDOLE-2-CARBOXYLIC ACID 3-CARBAMIMIDOYL-BENZYLESTER, ... (5 entities in total) |
| Functional Keywords | protein inhibitor complex, blood coagulation factor, serine proteinase, hydrolase |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted: P00742 P00742 |
| Total number of polymer chains | 2 |
| Total formula weight | 44226.95 |
| Authors | Schreuder, H.A.,Loenze, P.,Brachvogel, V.,Liesum, A. (deposition date: 2002-05-08, release date: 2003-05-08, Last modification date: 2021-10-27) |
| Primary citation | Matter, H.,Defossa, E.,Heinelt, U.,Blohm, P.M.,Schneider, D.,Mueller, A.,Herok, S.,Schreuder, H.A.,Liesum, A.,Brachvogel, V.,Loenze, P.,Walser, A.,Al-Obeidi, F.,Wildgoose, P. Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa J.Med.Chem., 45:2749-2769, 2002 Cited by PubMed: 12061878DOI: 10.1021/jm0111346 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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