1KLM

HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152

1KLM の概要

• エントリーDOI: 10.2210/pdb1klm/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE, ... (4 entities in total)
• 機能のキーワード: aids, hiv-1, endonuclease, rna-directed dna polymerase, hiv-1 reverse transcriptase, bhap u-90152, drug, nucleotidyltransferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116450.56

構造登録者

Ren, J.,Esnouf, R.M.,Stammers, D.K.,Stuart, D.I. (登録日: 1997-03-17, 公開日: 1998-03-18, 最終更新日: 2024-04-03)

• 主引用文献: Esnouf, R.M.,Ren, J.,Hopkins, A.L.,Ross, C.K.,Jones, E.Y.,Stammers, D.K.,Stuart, D.I.; Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.; Proc.Natl.Acad.Sci.USA, 94:3984-3989, 1997; PubMed: 9108091; DOI: 10.1073/pnas.94.8.3984

実験手法

X-RAY DIFFRACTION (2.65 Å)