1KLG

Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

1KLG の概要

• エントリーDOI: 10.2210/pdb1klg/pdb
• 関連するPDBエントリー: 1KLU
• 分子名称: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN, Triosephosphate isomerase peptide, ... (5 entities in total)
• 機能のキーワード: hla-dr1/tpi, enterotoxin c3, human melanoma antigen, cd4+ t cells, immune system-toxin complex, immune system/toxin
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Secreted: P0A0L5
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 71881.73

構造登録者

Sundberg, E.J.,Sawicki, M.W.,Andersen, P.S.,Sidney, J.,Sette, A.,Mariuzza, R.A. (登録日: 2001-12-11, 公開日: 2002-08-02, 最終更新日: 2021-10-27)

• 主引用文献: Sundberg, E.J.,Sawicki, M.W.,Southwood, S.,Andersen, P.S.,Sette, A.,Mariuzza, R.A.; Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.; J.Mol.Biol., 319:449-461, 2002; PubMed: 12051920; DOI: 10.1016/S0022-2836(02)00370-4

実験手法

X-RAY DIFFRACTION (2.4 Å)