1FYY

HPRT GENE MUTATION HOTSPOT WITH A BPDE2(10R) ADDUCT

1FYY の概要

• エントリーDOI: 10.2210/pdb1fyy/pdb
• NMR情報: BMRB: 4647
• 分子名称: HPRT DNA WITH BENZO[A]PYRENE-ADDUCTED DA7, 5'-D(*TP*GP*CP*CP*CP*TP*TP*GP*AP*CP*TP*A)-3', 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE (3 entities in total)
• 機能のキーワード: dna lesions, benzo[a]pyrene, hprt gene, diol epoxide adducts, syn-anti interconversion, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7629.15

構造登録者

Volk, D.E.,Rice, J.S.,Luxon, B.A.,Yeh, H.J.C.,Liang, C.,Xie, G.,Sayer, J.M.,Jerina, D.M.,Gorenstein, D.G. (登録日: 2000-10-03, 公開日: 2000-12-06, 最終更新日: 2022-02-23)

• 主引用文献: Volk, D.E.,Rice, J.S.,Luxon, B.A.,Yeh, H.J.,Liang, C.,Xie, G.,Sayer, J.M.,Jerina, D.M.,Gorenstein, D.G.; NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex.; Biochemistry, 39:14040-14053, 2000; PubMed: 11087351; DOI: 10.1021/bi001669l

実験手法

SOLUTION NMR