1E26

Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.

1E26 の概要

• エントリーDOI: 10.2210/pdb1e26/pdb
• 関連するPDBエントリー: 1DAJ 1DYR 2CD2 3CD2 4CD2
• 分子名称: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[2-(2-AMINO-4-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYL]GLUTAMIC ACID, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, dihydrofolate reductase, thymidylate synthase
• 由来する生物種: PNEUMOCYSTIS CARINII
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25087.38

構造登録者

Gangjee, A.,Yu, J.,McGuire, J.J.,Cody, V.,Galitsky, N.,Kisliuk, R.L.,Queener, S.F. (登録日: 2000-05-17, 公開日: 2001-05-17, 最終更新日: 2023-12-06)

• 主引用文献: Cody, V.,Galitsky, N.,Rak, D.,Luft, J.R.,Pangborn, W.,Queener, S.F.; Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+; Biochemistry, 38:4303-, 1999; PubMed: 10194348; DOI: 10.1021/BI982728M

実験手法

X-RAY DIFFRACTION (2 Å)