1AXR

COOPERATIVITY BETWEEN HYDROGEN-BONDING AND CHARGE-DIPOLE INTERACTIONS IN THE INHIBITION OF BETA-GLYCOSIDASES BY AZOLOPYRIDINES: EVIDENCE FROM A STUDY WITH GLYCOGEN PHOSPHORYLASE B

1AXR の概要

• エントリーDOI: 10.2210/pdb1axr/pdb
• 分子名称: GLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase, glycosidases, glycogen phosphorylase, catalytic mechanism, azolopyridines, inhibitors
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97930.47

構造登録者

Oikonomakos, N.G.,Heightman, T.D. (登録日: 1997-10-20, 公開日: 1998-01-28, 最終更新日: 2011-07-13)

• 主引用文献: Heightman, T.D.,Vasella, A.,Tsitsanou, K.E.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.; Cooperative interactions of the catalytic nucleophile and the catalytic acid in the inhibition of beta-glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b.; HELV.CHIM.ACTA, 81:853-864, 1998

実験手法

X-RAY DIFFRACTION (2.3 Å)