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1AXR

COOPERATIVITY BETWEEN HYDROGEN-BONDING AND CHARGE-DIPOLE INTERACTIONS IN THE INHIBITION OF BETA-GLYCOSIDASES BY AZOLOPYRIDINES: EVIDENCE FROM A STUDY WITH GLYCOGEN PHOSPHORYLASE B

Summary for 1AXR
Entry DOI10.2210/pdb1axr/pdb
DescriptorGLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywordstransferase, glycosidases, glycogen phosphorylase, catalytic mechanism, azolopyridines, inhibitors
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains1
Total formula weight97930.47
Authors
Oikonomakos, N.G.,Heightman, T.D. (deposition date: 1997-10-20, release date: 1998-01-28, Last modification date: 2011-07-13)
Primary citationHeightman, T.D.,Vasella, A.,Tsitsanou, K.E.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.
Cooperative interactions of the catalytic nucleophile and the catalytic acid in the inhibition of beta-glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b.
HELV.CHIM.ACTA, 81:853-864, 1998
Cited by
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

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