1A1Q

HEPATITIS C VIRUS NS3 PROTEINASE

1A1Q の概要

• エントリーDOI: 10.2210/pdb1a1q/pdb
• 分子名称: NS3 PROTEINASE, ZINC ION (2 entities in total)
• 機能のキーワード: hydrolase, serine protease
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 59880.04

構造登録者

Love, R.A.,Parge, H.E.,Wickersham, J.A.,Hostomsky, Z.,Habuka, N.,Moomaw, E.W.,Adachi, T.,Hostomska, Z. (登録日: 1997-12-12, 公開日: 1998-03-25, 最終更新日: 2024-02-07)

• 主引用文献: Love, R.A.,Parge, H.E.,Wickersham, J.A.,Hostomsky, Z.,Habuka, N.,Moomaw, E.W.,Adachi, T.,Hostomska, Z.; The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.; Cell(Cambridge,Mass.), 87:331-342, 1996; PubMed: 8861916; DOI: 10.1016/S0092-8674(00)81350-1

実験手法

X-RAY DIFFRACTION (2.4 Å)