1A1Q
HEPATITIS C VIRUS NS3 PROTEINASE
Summary for 1A1Q
Entry DOI | 10.2210/pdb1a1q/pdb |
Descriptor | NS3 PROTEINASE, ZINC ION (2 entities in total) |
Functional Keywords | hydrolase, serine protease |
Biological source | Hepatitis C virus |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663 |
Total number of polymer chains | 3 |
Total formula weight | 59880.04 |
Authors | Love, R.A.,Parge, H.E.,Wickersham, J.A.,Hostomsky, Z.,Habuka, N.,Moomaw, E.W.,Adachi, T.,Hostomska, Z. (deposition date: 1997-12-12, release date: 1998-03-25, Last modification date: 2024-02-07) |
Primary citation | Love, R.A.,Parge, H.E.,Wickersham, J.A.,Hostomsky, Z.,Habuka, N.,Moomaw, E.W.,Adachi, T.,Hostomska, Z. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell(Cambridge,Mass.), 87:331-342, 1996 Cited by PubMed: 8861916DOI: 10.1016/S0092-8674(00)81350-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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