8GDY
Crystal structure of the human PDI first domain with 9 mutations
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protein disulfide-isomerase | polymer | 141 | 15831.6 | 2 | UniProt (P07237) Pfam (PF00085) In PDB | Homo sapiens (human) | PDI,Cellular thyroid hormone-binding protein,Prolyl 4-hydroxylase subunit beta,p55 |
2 | A, B | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 137 (UniProt: P07237)
PDB | External Database | Details |
---|---|---|
Met -3 | - | initiating methionine |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
Ser 7 | - | expression tag |
Ser 8 | - | expression tag |
Gly 9 | - | expression tag |
Leu 10 | - | expression tag |
Val 11 | - | expression tag |
Pro 12 | - | expression tag |
Arg 13 | - | expression tag |
Gly 14 | - | expression tag |
Ser 15 | - | expression tag |
His 16 | - | expression tag |
Met 17 | - | expression tag |
Arg 31 | Lys 31 | engineered mutation |
Arg 42 | Lys 42 | engineered mutation |
Arg 57 | Lys 57 | engineered mutation |
Arg 65 | Lys 65 | engineered mutation |
Arg 69 | Lys 69 | engineered mutation |
Arg 71 | Lys 71 | engineered mutation |
Arg 114 | Lys 114 | engineered mutation |
Arg 130 | Lys 130 | engineered mutation |
Arg 131 | Lys 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 31663.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 178.2 | |
All* | Total formula weight | 31841.4 |