Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. LVeFYapWCGHCRaLapeY |
| Chain | Residue | Details |
| A | LEU45-TYR63 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | CYS53 | |
| A | CYS56 | |
| B | CYS53 | |
| B | CYS56 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Contributes to redox potential value |
| Chain | Residue | Details |
| A | GLY54 | |
| A | HIS55 | |
| B | GLY54 | |
| B | HIS55 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Lowers pKa of C-terminal Cys of first active site |
| Chain | Residue | Details |
| A | ARG120 | |
| B | ARG120 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 191 |
| Chain | Residue | Details |
| A | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | GLY54 | activator, modifies pKa |
| A | HIS55 | modifies pKa, proton acceptor, proton donor |
| A | CYS56 | |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 191 |
| Chain | Residue | Details |
| B | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLY54 | activator, modifies pKa |
| B | HIS55 | modifies pKa, proton acceptor, proton donor |
| B | CYS56 | |
