8F1C
Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Potassium voltage-gated channel subfamily C member 1 | polymer | 552 | 62745.3 | 4 | UniProt (P48547) Pfam (PF02214) Pfam (PF00520) In PDB | Homo sapiens (human) | NGK2,Voltage-gated potassium channel subunit Kv3.1,Voltage-gated potassium channel subunit Kv4 |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B, C, D | (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one | non-polymer | 437.9 | 4 | Chemie (X9T) | |||
| 4 | A, B, C, D | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 5 | A | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) |
Sequence modifications
A, B, C, D: 1 - 511 (UniProt: P48547)
| PDB | External Database | Details |
|---|---|---|
| Met -33 | - | expression tag |
| Ala -32 | - | expression tag |
| Asp -31 | - | expression tag |
| Tyr -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Asp -28 | - | expression tag |
| His -27 | - | expression tag |
| Asp -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Asp -24 | - | expression tag |
| Tyr -23 | - | expression tag |
| Lys -22 | - | expression tag |
| Asp -21 | - | expression tag |
| His -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Ile -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Lys -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Lys -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Val -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 512 | - | expression tag |
| Glu 513 | - | expression tag |
| Val 514 | - | expression tag |
| Leu 515 | - | expression tag |
| Phe 516 | - | expression tag |
| Gln 517 | - | expression tag |
| Gly 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 250981.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 5209.8 | |
| All* | Total formula weight | 256190.9 |
